Infants’ early intake of solid foods could bring later health risk

April 06, 2020

INFANTS who were started on solid foods at or before three months of age showed changes in the levels of gut bacteria and could lead to certain ailments as they grow.

According to researchers at Johns Hopkins Bloomberg School of Public Health, early introduction of solid foods to infants may predispose them to being overweight at least in part by altering the gut bacterial population and could increase their risk of diabetes and hypertension.

"How the early introduction of solid foods would cause the later development of obesity has been unknown, but our findings suggest that disruptions to gut bacteria may be one explanation," says Noel Mueller, PhD, assistant professor in the Department of Epidemiology at the Bloomberg School.

Pediatricians' associations typically recommend that infants be breastfed exclusively for the first four to six months, after which solid foods should be introduced as a supplement to breastmilk or milk formula.

Past research suggests that children who start eating solid foods earlier than six months are more likely to be overweight in childhood. Prior studies also indicate that the timing of solid food introduction may affect the chances of developing eczema, food allergies, asthma, hay fever, and other allergy-related conditions.

To understand better how the timing of solid food introduction, in terms of biological mechanisms, could affect a child's metabolic and/or immune health, Mueller and his colleagues analyzed data from 67 children. The researchers compared the timing of solid food introduction with the bacterial species and byproducts found in the month-3 and month-12 stool samples.

The team found that the samples from infants who had started on solid foods at or before three months, at the month-3 time point and even at the month-12 time point, contained a significantly higher diversity of bacteria, indicating a more diverse gut bacterial population or "microbiome," compared to samples from infants who had started later on solid foods.

The researchers also measured the stool-sample levels of organic bacterial byproducts called short-chain fatty acids. Prior studies have linked higher stool levels of butyric acid and other short-chain fatty acids in adults to increased risks of obesity, diabetes, and hypertension.

Mueller and colleagues found in their study that infants starting on solid foods by three months had significantly higher concentrations of butyric acid, as well as total short-chain fatty acids, at 12 months -- but not at 3 months, which could indicate a delayed and sustained impact of early solid-food introduction.

Mueller concludes that the findings are consistent with the emerging evidence that gut microbiome changes are key factors in the development of common metabolic and immune conditions, and suggest that scientists are on the right track in studying these changes.

However, they said further research is needed to determine if these measures of microbiome diversity and short-chain fatty acid concentration truly drive the development of obesity and other disorders.

Mueller and colleagues are continuing to conduct studies of diet and the gut microbiome in infants and children, and the associations between these factors and outcomes such as obesity and immune-related disorders.

(Johns Hopkins University Bloomberg School of Public Health/ScienceDaily)