The Utah Jazz launch the rebooted campaign against the New Orleans Pelicans before LeBron James and Kawhi Leonard go head-to-head in a heavyweight Los Angeles derby between the Lakers and the Clippers.
The two games mark the start of a painstakingly crafted plan to stage the remainder of the basketball season safely in the midst of an ongoing pandemic which has already claimed around 150,000 lives in the United States.
To mitigate the risks, the NBA is basing 22 teams within a tightly controlled "bubble" inside Disney World's sprawling 40-square mile campus in Orlando.
Teams will play games at three venues inside the ESPN World Wide of Sports complex inside the park, with no fans in attendance and only a smattering of journalists at each game.
Just over 350 players will be housed at three hotels located throughout Disney World, with access to each location severely restricted and visits from outsiders strictly forbidden until the playoffs start.
Players arriving in Orlando were required to spend 48 hours isolated in their hotel rooms until they had received two negative tests for COVID-19.
Testing will continue inside the bubble but it is not known how frequently this will take place.
While multi-millionaire stars such as the Lakers' James have joked that entering the bubble felt like starting a jail term, so far the launch of the project has gone smoothly.
Practice games have passed off without a hitch, and the most recent round of testing found zero positive cases out of 346 players tested.
"It requires significant sacrifice from our players," NBA commissioner Adam Silver told the New York Times this week.
"From my standpoint, it's going very well, and I'm cautiously optimistic that we’re on the right track," Silver added.
"But I also recognize what we're doing has not been done before, and the competition is just beginning. The real test will come when players are commingling, playing basketball without masks and without physical distancing."
There have been some early glitches however as players adjust to the relatively spartan surroundings of the bubble.
Los Angeles Clippers guard Lou Williams was forced to quarantine for 10 days after being photographed at an Atlanta strip club during a trip to attend a family funeral.
The Sacramento Kings' Richaun Holmes also landed back in quarantine after he left the bubble to pick-up a delivery of take-out food.
Inside the bubble's three arenas, meanwhile, the legacy of the tumultuous protests which erupted in the weeks following the death of George Floyd in May will be on full view.
Giant "Black Lives Matter" slogans have been written on each court, while players will be allowed to wear jerseys adorned with social justice messages ranging from "I Can't Breathe" to "Justice Now" and "Education Reform."
LEBRON, GIANNIS ON POLE
On the courts, all eyes will be on James and his Lakers teammates as they attempt to return to the pinnacle of the NBA when the season wraps in October.
After a disappointing first season in Los Angeles, where the Lakers failed to reach the playoffs, James returned with a vengeance this season, leading the team to the top of the Western Conference before the COVID-19 pandemic erupted.